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- (verb): Short for mainline.
- (verb): To mainly play a specific character, or side, during a game.
- (verb): Of a road: to convert into a main or primary road.
- (adjective): Of chief or leading importance; prime, principal.
- (adjective): Chief, most important, or principal in extent, size, or strength; consisting of the largest part.
- (adjective): (of force, strength, etc.) Full, sheer, undivided.
- (adjective): Big; angry.
- (adjective): Belonging to or connected with the principal mast in a vessel.
- (adjective): Great in size or degree; important, powerful, strong, vast.
- (adverb): Exceedingly, extremely, greatly, mightily, very, very much.
- He mains the same character as me in that game.
- main timbers main branch of a river main body of an army