ruin

(noun): (sometimes in the plural) The remains of a destroyed or dilapidated construction, such as a house or castle.
(noun): The state of being a ruin, destroyed or decayed.
(noun): Something that leads to serious trouble or destruction.
(noun): A fall or tumble.
(noun): A change that destroys or defeats something; destruction; overthrow.
(noun): Complete financial loss; bankruptcy.
(verb): To cause the fiscal ruin of.
(verb): To destroy or make something no longer usable.
(verb): To cause severe financial loss to; to bankrupt or drive out of business.
(verb): To upset or overturn the plans or progress of, or to have a disastrous effect on something.
(verb): To make something less enjoyable or likeable.
(verb): To reveal the ending of (a story); to spoil.
(verb): To fall into a state of decay.
(verb): To seduce or debauch, and thus harm the social standing of.

The monastery has fallen into ruin.
Gambling has been the ruin of many.
the ruin of a ship or an army; the ruin of a constitution or a government; the ruin of health or hopes
With all these purchases, you surely mean to ruin us!
He ruined his new white slacks by accidentally spilling oil on them.