son of a bitch

(noun): An objectionable, despicable person.
(noun): Any objectionable thing.
(interjection): Used to express anger, contempt, astonishment, disappointment etc.

“My mother never saw the irony in calling me a son of a bitch.” — attributed to various people, such as Jack Nicholson and Richard Jeni
"This son of a bitch won’t move!" Marty exclaimed as he grappled with the supermarket cart.